Entresto Price Relief? What to Know About Generics and Discounts

Heart failure affects millions worldwide. Entresto, a groundbreaking medication, has changed how heart failure with reduced ejection fraction (HFrEF) is treated. But with rising prescription costs, patients frequently ask: Is there a generic version of Entresto? In 2025, the Entresto Generic question has taken on new importance.

This comprehensive guide dives deep into Entresto generic updates, cost-saving options, Medicare coverage, and practical tips to access the medication at a lower price—even as low as $10.

What Is Entresto?

Entresto is a prescription medication that combines two active ingredients:

• Sacubitril (a neprilysin inhibitor)

• Valsartan (an angiotensin receptor blocker – ARB)

Together, these help the heart pump more efficiently and reduce strain. Entresto is primarily prescribed for:

• Chronic heart failure (HFrEF)

• Reducing hospitalization risk due to heart failure

• Improving survival in heart failure patients

How Entresto Works in the Body

Entresto works by relaxing blood vessels, reducing sodium retention, and decreasing stress on the heart. Sacubitril increases levels of peptides that cause vasodilation, while valsartan blocks substances that tighten blood vessels.

The dual-action formula provides superior results compared to ACE inhibitors or ARBs alone, which is why cardiologists strongly favor Entresto for eligible patients.

Is There a Generic of Entresto in 2025?

As of 2025, no FDA-approved generic version of Entresto is available in the United States. The original manufacturer, Novartis, holds the patent rights.

Patent Status:

• Original approval: 2015

• Expected patent expiration: 2026 or later (depending on challenges or extensions)

Off-brand availability:

• In some international markets, biosimilar or equivalent medications may surface.

• No U.S. generics are permitted yet due to exclusivity rights.

Pro Tip: Keep checking the FDA’s Orange Book for status updates.

Why a Generic Entresto Matters

The cost of name-brand medications is a significant barrier for many patients. A generic version would potentially slash costs by 70% or more.

Benefits of Generics:

• Lower out-of-pocket costs

• Wider accessibility

• Reduced burden on insurance systems

• Potential for Medicare Tier 1 classification

Until a generic hits the market, alternatives for reducing costs become crucial.

Cost Comparison: Entresto vs. Entresto Generic

As of 2025, Entresto (brand name) costs an average of $550 to $650 per month without insurance. For those with insurance, copays usually range between $30 and $100, depending on the plan. Some manufacturer discount programs may bring the cost down to as low as $10 per month.

A generic version of Entresto is not yet available, but projected prices—once it is released—could range from $50 to $150 per month. Insurance copays and discount programs for the generic will depend on availability and approval status.

📝 Note: Prices vary based on your pharmacy, location, and insurance plan.

Is There a Cheaper Version of Entresto?

Yes—while no official generic exists yet, there are alternative ways to reduce costs:

1. Manufacturer Coupons

Novartis offers co-pay assistance for qualifying patients. Search “Entresto $10 card” on the official Entresto site.

2. Patient Assistance Programs

Through Partnership for Prescription Assistance, eligible individuals can get medication for free or at reduced cost.

3. Pharmacy Discount Cards

Apps like GoodRx and SingleCare list discounts that bring Entresto’s price down.

Medicare and Entresto Coverage

Medicare Part D plans generally cover Entresto, but coverage levels and copays differ.

What to Know:

• Formulary Tier: Often Tier 3 or 4 (higher copays)

• Coverage Gap: Out-of-pocket increases during the “donut hole”

• Prior Authorization: Some plans require doctor pre-approval

Tip: Use Medicare Plan Finder annually to compare plans that cover Entresto affordably.

How to Get Entresto for $10

Believe it or not, many patients qualify to get Entresto for just $10 a month.

Steps:

1. Visit Entresto.com

2. Apply for the Co-Pay Savings Card

3. Check income eligibility for the Novartis Patient Assistance Foundation

4. Compare discount prices using GoodRx or Blink Health

5. Ask your doctor for a 90-day supply prescription (cheaper in bulk)

Potential Side Effects of Entresto

While highly effective, Entresto isn’t without side effects.

Common Side Effects:

• Dizziness

• Low blood pressure

• Cough

• Kidney problems

Serious but Rare:

• Hyperkalemia (high potassium)

• Angioedema (swelling under the skin)

• Severe hypotension

Report any adverse effects to the FDA’s MedWatch Program.

Who Should Avoid Entresto?

Entresto isn’t for everyone. Avoid it if you:

• Are you pregnant or planning a pregnancy

• Have a history of angioedema

• Are you taking ACE inhibitors or Aliskiren

• Have severe liver disease

Always consult your physician before starting or stopping any heart medication.

Natural Alternatives to Entresto

While not replacements, lifestyle changes can support heart health:

Diet:

• DASH Diet

• Low sodium, high potassium foods

Supplements:

• CoQ10

• Omega-3 fatty acids

Lifestyle:

• Regular moderate exercise

• Stress management

• Weight control

Warning: Never replace prescribed medication with supplements without a doctor’s approval.

Doctor’s Insight on Entresto Generic

We interviewed cardiologist Dr. Lisa Benton:

“Patients often ask when Entresto will have a generic. While we expect one soon after 2026, current assistance programs do a great job of bridging the affordability gap. Until then, patient education and smart pharmacy shopping are key.”

What to Expect When Switching to Generic Entresto

Once a generic is available, you may notice:

• Similar therapeutic effects

• Slight differences in pill appearance

• Adjustments in dosage may be necessary

• Insurance may automatically switch you to the generic

Stay in close communication with your healthcare provider during the transition.

FAQs

Is there a generic of Entresto?

Not yet. As of 2025, Entresto still does not have a generic equivalent approved by the FDA.

Is there a cheaper version of Entresto?

Yes. You can access Entresto for as low as $10 through manufacturer coupons and savings programs.

Is Entresto covered by Medicare?

Yes, under Medicare Part D plans. Coverage and copays vary based on your plan.

How to get Entresto for $10?

Apply for the Entresto Co-Pay Card via the manufacturer’s website and explore assistance programs like PPA or state pharmacy assistance.

Is Entresto safe long term?

Studies show Entresto is safe for long-term use under medical supervision, especially when regularly monitored for side effects.

What happens if you stop Entresto suddenly?

Stopping abruptly can cause heart failure symptoms to worsen. Always consult your doctor first.

Final Thoughts

Entresto continues to lead in heart failure treatment, offering hope and extended quality of life. While a generic isn’t available in 2025, various cost-saving options like $10 co-pay cards, discount pharmacies, and Medicare plans make it more accessible than ever.

Patients are encouraged to stay informed, work with their healthcare providers, and watch for updates on generic availability post-2026. Until then, making smart choices around insurance and pharmacy benefits can significantly reduce your monthly costs.

One step closer to better Medicare coverage—get your free quote at NewMedicare.com or call 📞 (833) 203-6742!